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KMID : 0385520160290040186
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Analytical Science & Technology
2016 Volume.29 No. 4 p.186 ~ p.193
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The anti-histamine effect of water soluble alkaloids extracted from solanum nigrum L.
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Shen Chang-Zhe
Park Jung-Keun
Kim Choul-Goo
Chun Hyun-Ja
Kim Il-Kwang
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Abstract
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The whole herbs of solanum nigrum L were extracted in boiling water (SNL-W), and the extracts were separated with butyl alcohol fraction (SNL-W/B) and aqueous fraction (SNL-W/W) by the solvent extraction method. The total alkaloid and total saponin content mensuration were used to identify the alkaloid composition of methanol fraction extracted from the aqueous fraction. The venom of honey bee was used to induce the rat peritoneal mast cell to secreting the histamine. The results show that the water soluble alkaloid composition of solanum nigrum L (SNL-W/W/M) has a significant inhibitory effect on the histamine release.
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KEYWORD
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solanum nigrum L, alkaloid, histamine, honey bee venom,
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